Chromosome Function and Mutation

Chromosome Function and Mutation A chromosome is a long, stringy aggregate of genes that carries heredity information and is formed from condensed chromatin. Chromatin is composed of DNA and proteins that are tightly packed together to form  chromatin fibers. Condensed chromatin fibers form chromosomes. Chromosomes are located within the nucleus of our cells. They are paired together (one from the mother and one from the father) and are known as homologous chromosomes. During cell division, chromosomes are replicated and distributed equally among each new daughter cell. Key Takeaways: Chromosomes Chromosomes are composed of DNA and proteins packed tightly to form long chromatin fibers. Chromosomes house genes responsible for the inheritance of traits and guidance of life processes.Chromosome structure consists of a long arm region and a short arm region connected at a central region known as a centromere. The ends of a chromosome are called telomeres.Duplicated or replicated chromosomes have the familiar X-shape and are composed of identical sister chromatids.During cell division, sister chromatids separate and are incorporated into new daughter cells.Chromosomes contain the genetic codes for protein production. Proteins regulate vital cellular processes and provide structural support for cells and tissues.Chromosome mutations result in changes in chromosome structure or changes in cellular chromosome numbers. Mutations most often have harmful consequences. Chromosome Structure A telomere is a region of the DNA sequence at the end of a chromosome. Their function is to protect the ends of the chromosome from degradation. Here they are visible as highlights at the tips of the chromosomes. Credit: Science Picture Co/Subjects/Getty Images A non-duplicated chromosome is single-stranded and consists of a centromere region that connects two arm regions. The short arm region is called the p arm and the long arm region is called the ​q arm. The end region of a chromosome is called a telomere. Telomeres consist of repeating non-coding DNA  sequences that get shorter as a cell divides. Chromosome Duplication Chromosome duplication occurs prior to the division processes of mitosis and meiosis. DNA replication processes allow correct chromosome numbers to be preserved after the original cell divides. A duplicated chromosome is comprised of two identical chromosomes called sister chromatids that are connected at the centromere region. Sister chromatids remain together until the end of the division process where they are separated by spindle fibers and enclosed within separate cells. Once the paired chromatids separate from one another, each is known as a daughter chromosome. Chromosomes and Cell Division Chromosomes are threadlike structures composed of DNA and proteins. During cell division, chromosomes consist of two arms, or chromatids, which are joined by a centromere. Joined chromatids are called sister chromatids. Credit: Adrian T Sumner/The Image Bank/Getty Images One of the most important elements of successful cell division is the correct distribution of chromosomes. In mitosis, this means that chromosomes must be distributed between two daughter cells. In meiosis, chromosomes must be distributed among four daughter cells. The cells spindle apparatus is responsible for moving chromosomes during cell division. This type of cell movement is due to interactions between spindle microtubules and motor proteins, which work together to manipulate and separate chromosomes. It is vitally important that a correct number of chromosomes be preserved in dividing cells. Errors that occur during cell division may result in individuals with unbalanced chromosome numbers. Their cells may have either too many or not enough chromosomes. This type of occurrence is known as aneuploidy and may happen in autosomal chromosomes during mitosis or in sex chromosomes during meiosis. Anomalies in chromosome numbers can result in birth defects, developmental disabilities, and death. Chromosomes and Protein Production DNA is transcribed and translated to produce proteins. Reverse transcription converts RNA to DNA. ttsz/iStock/Getty Images Plus   Protein production is a vital cell process that is dependent upon chromosomes and DNA. Proteins are important molecules that are necessary for almost all cell functions. Chromosomal DNA contains segments called genes that code for proteins. During protein production, the DNA unwinds and its coding segments are transcribed into an RNA transcript. This copy of the DNA message is exported from the nucleus and then translated to form a protein. Ribosomes and another RNA molecule, called transfer RNA, work together to bind to the RNA transcript and convert the coded message into a protein. Chromosome Mutation Genetic Mutation. BlackJack3D/E/Getty Images Chromosome mutations are changes that occur in chromosomes and are typically the result of either errors that happen during meiosis or by exposure to mutagens such as chemicals or radiation. Chromosome breakage and duplications can cause several types of chromosome structural changes that are typically harmful to the individual. These types of mutations result in chromosomes with extra genes, not enough genes, or genes that are in the wrong sequence. Mutations can also produce cells that have abnormal numbers of chromosomes. Abnormal chromosome numbers typically occur as a result of nondisjunction or the failure of homologous chromosomes to separate properly during meiosis.

Egyptian Civilization essays

Egyptian Civilization essays Egyptian civilization formed along the Nile river and the earliest traces of human life in that region are from the Paleolithic Age, (Old Stone Age), about 300,000 B.C., at the very edges of the Nile Valley. Beyond, on both sides of the river the land was and still is desert. At that time the people moved from place to place, ate berries, roots, and any animals they could find, but stood close to their lifeline, the Nile. The lands along the Nile were rich enough to be farmed, so over time the people started to grow crops. They found ways to store the yearly floodwaters and then use them for the dry seasons. The farmers learned to lift water out of the Nile or wells and send it across the fields through a system of canals. In order for all of this to work out they had to work together, no one could do any of it alone. So as the farmers and people began to cooperate, an organization began to grow. They found leaders among them who directed the work. A form of government developed and due to that they soon began to build cities, to manufacture things, in time to trade with their neighbors. That is how it all started. Over a period from 3100 B.C. to 332 B.C. they grew in culture, arts, religion, science, The early Egyptian people grew food by the Nile and lived mainly by hunting for meat, fishing, and gathering wild plants. They kept a small number of cattle, sheep, or goats, and grew a few crops. Their crops were flax, barley, and a primitive kind of wheat called 'emmer.' They got the sheep and goats from the middle east, and their crops too. Farming provided most of the food and helped their population grow. Later on in time, the basic diet of the ordinary people was bread and beer. The wealthier ones ate more meat and drank wine instead of The most common clothes women wore were tunic dresses. Those were made by folding a rectangle of cloth in half, sewing it up at the sides, leaving ...

Vehicle Routing Software Assignment Example | Topics and Well Written Essays - 500 words

Vehicle Routing Software - Assignment Example These are several factors that are considered by clients when installing the vehicle routing system; durability, efficiency, installation and maintenance cost and detailed data. This software helps in; There are several software companies that offer vehicle routing service with both similar and different features .Some of the key features of vehicle routing software’s are constraint programming platform ,ability to tackle large and complex species problems, precise modeling ,operation research derived routing algorithm and immediate tangible benefits Appian is transport management software used for truck routing, logistic support analysis and designs. It is the easiest way to make fleet location and routing accessible to both the company and clients. It updates schedules automatically based on the real time GPS feed .It is able to mage easily territory overlaps quick return on investments. It allows incorporation Microsoft excel software. In apian there is resource scheduling and fleet sizing optimization software that provide crucial information for fleet scheduling, strategic growth plan and eliminating unnecessary cost. MJC2 is vendor that offers powerful planning and optimization solutions. It has advanced planning and scheduling software that is capable of providing automated scheduling and optimizing the operation with minimal manual intervention. This software is user friendly and has powerful scheduling control functionality. It also has e- enabled scheduler that allows web scheduling to be online and able to corporate databases and legacy system. It’s able to address the scheduling of very large distribution operation in real time and provide strategic supply chain management. Some other extra benefits are ability to quickly update round because demand varies, better utilization of resources and long term planning powers The vendor has product for real time routing and

The Importance of Water and the Hydrologic Cycle Essay

The Importance of Water and the Hydrologic Cycle - Essay Example NRDC arranged to test 1000 portable water bottles comprising of 103 brands available in the US market. NRDC conducted a detailed investigation that lasted for four years. Usually, producers of the bottled water maintain that their products are free of any chemical contaminants. Some of the samples collected were found to be contaminated with E-coli Bacteria, Arsenic, Nitrate, chloroform, phthalates, and some other kinds of bacteria that can cause serious illnesses to those who consume it. Infection with E-Coli bacteria can cause diarrhea, and vomit to children, elderly people and those who body immune system is weak. Substances such as Arsenic are considered carcinogenic and can lead to nervous, skin and reproductive issues. Nitrate interferes with blood's oxygen intake ability, especially in infants. Nitrates also increase cancer risk. The substance such as chloroform can cause cancer of the pancreas, colon; it may also cause miscarriage or birth defects in newborns (NRDC, 2013).NRD C clarifies that not all brands were contaminated with harmful substances. Almost 25% of the bottled water, with at least one sample tested of each brand, was found to be violating state standards. Some of them were comparable to tap water; however, NRDC clarifies that these brands are not without risk because most brands were tested only a few times; NRDC has called their tests as 'snapshot' tests. It is also likely that source water quality due to different surface water sources varies significantly time to time.

Effects of race on the perception of Guilt Essay Example for Free

Effects of race on the perception of Guilt Essay Affective mood disorders are mental disorders characterised by disturbances in mood and emotional states, unlike Schizophrenia, the most severe of mental disorders, which is distinguished by problems with thought processes. These affective mood disorders can include variations such as Bipolar disorders where the patient experiences two extreme states; mania accompanied with depression and Unipolar disorders where only the depressive state is present. There have been many suggestions as to the cause of these disorders. It has long been thought that there are two types of depression: reactive and endogenous. Reactive depression follows the psychodynamic view that depression relates to life events such as loss of a loved one and endogenous depression mirrors the cognitive approach where the individual attributes failures internally thus bringing on depression. However the DSM-IV only lists two sub-types of depression, which are reliant upon the length that the patient has suffered for. These are major depressive disorder and dysthymic disorder. Biochemical explanations are mainly associated with unipolar depression and were developed in the 1950s with the introduction of Tricyclic drugs, which were discovered to help those with depressive symptoms. It has been suggested that chemical imbalances in the brain cause these depressive symptoms. Neurotransmitters such as serotonin, norepinephrine and dopamine are believed to be of a higher level in patients with no signs of depression compared to lower levels in those with depression (Schildkraut, Green and Mooney, 1985, in Gleitman et al, 1999) However, it is only possible to investigate this by measuring the by-products of the metabolising neurotransmitters. Although it has been found that patients with depression have lower levels of these by-products, Cooper (1988, in Cardwell et al, 2000) carried out post-mortems on patients who had suffered from depression and found that there was no abnormality in the chemicals of the brain. Medications used to treat depression can be used in support of the biochemical hypothesis as drugs such as Lithium and Tricyclic antidepressants increase the levels of norepinephrine and serotonin in the brain implying that it was the shortage of these chemicals that was causing the depression. Rosenzwig, Leiman and Breedloves (1996, in Gleitman et al, 1999) experiment also supports this view as it was discovered that lowering the levels of the neurotransmitters works in reverse and can cause depression. However, these anti-depressant drugs cause an immediate increase in the levels of norepinephrine, following the biochemical hypothesis once the norepinephrine level is increased depressive symptoms should disappear. In fact it takes 2-3 weeks after first taking the drugs for an effect to be seen, yet within a couple of days after taking the drugs the norepinephrine levels have returned to their previous level. This hinders the biochemical hypothesis and suggests that it may not purely be a chemical imbalance that causes depression. Patients who suffer with bipolar depression also have low levels of norepinephrine during a depressed phase, returning to a higher level when in a manic stage, (Muscettola et al, 1984,in Gleitman et al, 1999) the switch between the manic and depressive phases occur very quickly and without external influences, indicating that it is in fact a biological rather than psychological reason that causes this switch to take place. Another strand to the biological approach is the question; does depression run in families? The biological explanation supports this suggestion. There have been numerous twin studies comparing concordance rates of MZ (identical twins) with DZ (non-identical) twins, all giving evidence for some genetic transmission. Evidence for a genetic link concerning bipolar disorders comes from a study carried out by Hodgkinson, Mullan and Gurling, (1990, in Gleitman et al, 1999); they discovered that patients who had bipolar disorder also had an enzyme deficiency accompanied by a type of colour blindness. All of these irregularities are caused by a defect on the X-chromosome. This indicates that the genetic cause of bipolar disorder also lies with the x-chromosome and may explain to a certain degree why it has been found that more women than men suffer from bipolar depression. However it is important to note that women, no matter what culture have a different social support structure to men, allowing them to talk more about their problems. Therefore it may simply be the case that more women report their problems than men, who keep their feelings of depression to themselves. This difference also occurs with unipolar depression and can be accounted for by the vast amounts of hormonal changes women endure through menstruation, child carrying and the menopause. McGuffin et al (1996) compared 109 pairs of twins and found a rate of 46 per cent concordance in MZ twins to that of 20 per cent in DZ twins; this study shows a genetic link for depression but that it is not the only factor. If depression were only caused by genetics then the concordance rates would be 100 per cent for MZ twins and 50 per cent for DZ twins, suggesting that other factors play an important role. This genetic link may be due to environmental factors as the patients are likely to live in a shared environment. This suggests that the concordance rates occur not because depression is hereditary but because it can be learnt. This however could also work in reverse; a relative may not suffer from depression because they have experienced depression and have learnt ways to cope with their feelings and experiences. This can also be illustrated by Siever, Davis, and Gorman, (1991, in Gleitman et al, 1999) who carried out twin studies that showed identical twins were four times more likely to both suffer from a mood disorder than non-identical twins. Identical twins have a closer shared environment than non-identical twins, which may account for the higher concordance rate amongst identical twins.

Marriage and Love in Elizabethan England Essays -- European History Es

Marriage and Love in Elizabethan England The movie, Shakespeare in Love, provides insight into the world of Elizabethan England. Through the character of Viola De Lessups the audience is shown how marriage was an institution entered into not for love, but as a strategic maneuver designed to enhance the lives of those who would benefit from a union, whether or not the beneficiaries were the people actually exchanging vows. As Queen, Elizabeth I chose not to enter into such a union. She expressed the thoughts and feelings she had about the subject in both her speech, â€Å"On Marriage† and her poem â€Å"On Monsieur’s Departure.† A comparison of the character of Viola to the real life Queen of England, Elizabeth I, can provide the reader a greater understanding of marriage and love in Elizabethan England. Queen Elizabeth and Viola both realized that their station in life would determine their prospects for marriage. Elizabeth had the power to decide not to marry. Viola’s marriage to Wessex decided for her as â€Å"a daughter’s duty and the Queen’s command†(Shakespeare).[2] Viola is the daughter of a wealthy merchant and while she is â€Å"not so well born† she is, as her nurse points out, â€Å"Well moneyed† which â€Å"is the same as well born† and â€Å"well married is more so† (Shakespeare). Likewise, Elizabeth knew that if the Queen of England were to marry she would have to make a union that would benefit her country. She felt pressure from Parliament to marry and addressed it in her speech, â€Å"On Marriage†, given to Parliament in 1559. She assured them that they could put that idea â€Å"clean out of [their] heads† for â€Å"whensoever it may please God to incline [her] heart to anothe r kind of life,† she intended â€Å"not to do... ...n that she understood that duty prevented her from such a marriage. In her poem, â€Å"On Monsieur’s Departure† she allows a glimpse into the pain it caused her to be unable to fully pursue a life of love. Works Cited: [1] William Shakespeare, â€Å"Sonnet CXVI†, The Longman Anthology of British Literature: The Early Modern Period, ed. David Damrosch, 2nd ed., vol 1B (NewYork: Longman, 2003) 1233-34. [2] Shakespeare in Love, dir. John Madden, Perf. Gwyneth Paltrow, Joseph Fiennes. Mirimax/Universal, 1998. [3] Elizabeth I, â€Å"On Marriage,† The Longman Anthology of British Literature: The Early Modern Period, ed. David Damrosch, 2nd ed., vol 1B (NewYork: Longman, 2003) 1084-85. [4] Elizabeth I, â€Å"On Monsieur’s Departure,† The Longman Anthology of British Literature: The Early Modern Period, ed. David Damrosch, 2nd ed., vol 1B (NewYork: Longman, 2003) 1081-82.

Human Physical Appearance Essay

The appearances of people is like their cover, that? s why it? s so important, because it? s what can be seen, the first thing you note in a person, and like it or not, it tells a lot. It? s like a book, most of the time it? s judged by it? s front page, the right thing would be to read the review where you can know the details of it? s content, but what do you notice first? That why I compare the human appearance with a book, and I affirm that you can? t know a person only by the way they look, because it?  s not always what it seems, wearing designers clothes not necessarily shows your economic status and you can? t know a person only by their physical appearance, because this can be modified by a very important factor, self-esteem According to the Pequeno Larousse Ilustrado (1976), Appearance is â€Å" the outside look of a person or thing†. In another words is peoples physics, but there are situations in which the person can be criticized by this, specially during the te enage, that are the years of physical and mental development, but the physical part is commonly judged. Are we really conscious of what we say about other people? , I? m not saying it? s wrong, because the physical appearance is important, but is it all?. The appearance are not always what they look like, and even more in the teenage, the psychiatrist Felix Loracca says that we are modeling are personality in function of what others expect from us. For example, psychologists say that women tend to want to be accepted, not so much for their personality but for them to feel prettier. Young men present a similar case, now that they pay a lot of attention to their physical appearance, without neglecting their clothes, their hair, etc. The way each and every one of the teenagers practice their personal care for their appearance changes from one to another, but basically the aim is the same one, â€Å"try to look good†. Teenagers not only change their clothes, but their response, their expressions, their vocabulary and recreative activities. The way they dress and the physical appearance become very important, it can be a way to express solidarity with their friends, or as a way to declare their growing independence from their families. Another important aspect to consider is that clothing not necessarily proves your economical status, and this is more discussable nowadays, because material things don’t tell who you really are, a good example of this is Mahatma Gandhi, who despite of everything he owned economically speaking, acted like the most humble person in the world. People use to go for others clothing. Physical appearance influence, but is not determinant when we meet someone, and you can’t determine their economy, or their education by this, because everybody can have any kind of clothes or material objects without mattering the cost of these, there is who say â€Å"fashion, what suits you† and people can dress according with what they feel comfortable with without caring what other people think about them. Elton Mayo says that human relationships are majorly based in ties that exist between the members of society, thanks to communication, that can have many ways: principally visual, linguistically, affective and by specially created languages for the development of complex societies, that’s why he affirms that there is some importance in the physical appearance. One of the human needs is to relate with other living creatures, like Maslow shows in his hierarchical pyramid, in the affiliation is the friendship, or the creation of relations with other people. But in any moment he affirms the importance of the physical appearance. The changes in how we look to others are related with our self-esteem and not to our auto-perception, that’s why any change in our physical appearance can affect our present ME status, if we don’t have the ability to accept and adapt to these changes, in the same way this affects directly in our emotional status. In conclusion, physical appearances are an important part of people presence, but they are not determinant in the way to judge them, for what we saw previously. They exist an infinity of questions that we can make as thinking beings, that we lead us to much more questions, but it all ends in ourselves, the answer is in each one of us, you decide what to base in, how to act with others and how you want them to see you, but without losing your own personality.