Chromosome Function and Mutation

Chromosome Function and Mutation A chromosome is a long, stringy aggregate of genes that carries heredity information and is formed from condensed chromatin. Chromatin is composed of DNA and proteins that are tightly packed together to form  chromatin fibers. Condensed chromatin fibers form chromosomes. Chromosomes are located within the nucleus of our cells. They are paired together (one from the mother and one from the father) and are known as homologous chromosomes. During cell division, chromosomes are replicated and distributed equally among each new daughter cell. Key Takeaways: Chromosomes Chromosomes are composed of DNA and proteins packed tightly to form long chromatin fibers. Chromosomes house genes responsible for the inheritance of traits and guidance of life processes.Chromosome structure consists of a long arm region and a short arm region connected at a central region known as a centromere. The ends of a chromosome are called telomeres.Duplicated or replicated chromosomes have the familiar X-shape and are composed of identical sister chromatids.During cell division, sister chromatids separate and are incorporated into new daughter cells.Chromosomes contain the genetic codes for protein production. Proteins regulate vital cellular processes and provide structural support for cells and tissues.Chromosome mutations result in changes in chromosome structure or changes in cellular chromosome numbers. Mutations most often have harmful consequences. Chromosome Structure A telomere is a region of the DNA sequence at the end of a chromosome. Their function is to protect the ends of the chromosome from degradation. Here they are visible as highlights at the tips of the chromosomes. Credit: Science Picture Co/Subjects/Getty Images A non-duplicated chromosome is single-stranded and consists of a centromere region that connects two arm regions. The short arm region is called the p arm and the long arm region is called the ​q arm. The end region of a chromosome is called a telomere. Telomeres consist of repeating non-coding DNA  sequences that get shorter as a cell divides. Chromosome Duplication Chromosome duplication occurs prior to the division processes of mitosis and meiosis. DNA replication processes allow correct chromosome numbers to be preserved after the original cell divides. A duplicated chromosome is comprised of two identical chromosomes called sister chromatids that are connected at the centromere region. Sister chromatids remain together until the end of the division process where they are separated by spindle fibers and enclosed within separate cells. Once the paired chromatids separate from one another, each is known as a daughter chromosome. Chromosomes and Cell Division Chromosomes are threadlike structures composed of DNA and proteins. During cell division, chromosomes consist of two arms, or chromatids, which are joined by a centromere. Joined chromatids are called sister chromatids. Credit: Adrian T Sumner/The Image Bank/Getty Images One of the most important elements of successful cell division is the correct distribution of chromosomes. In mitosis, this means that chromosomes must be distributed between two daughter cells. In meiosis, chromosomes must be distributed among four daughter cells. The cells spindle apparatus is responsible for moving chromosomes during cell division. This type of cell movement is due to interactions between spindle microtubules and motor proteins, which work together to manipulate and separate chromosomes. It is vitally important that a correct number of chromosomes be preserved in dividing cells. Errors that occur during cell division may result in individuals with unbalanced chromosome numbers. Their cells may have either too many or not enough chromosomes. This type of occurrence is known as aneuploidy and may happen in autosomal chromosomes during mitosis or in sex chromosomes during meiosis. Anomalies in chromosome numbers can result in birth defects, developmental disabilities, and death. Chromosomes and Protein Production DNA is transcribed and translated to produce proteins. Reverse transcription converts RNA to DNA. ttsz/iStock/Getty Images Plus   Protein production is a vital cell process that is dependent upon chromosomes and DNA. Proteins are important molecules that are necessary for almost all cell functions. Chromosomal DNA contains segments called genes that code for proteins. During protein production, the DNA unwinds and its coding segments are transcribed into an RNA transcript. This copy of the DNA message is exported from the nucleus and then translated to form a protein. Ribosomes and another RNA molecule, called transfer RNA, work together to bind to the RNA transcript and convert the coded message into a protein. Chromosome Mutation Genetic Mutation. BlackJack3D/E/Getty Images Chromosome mutations are changes that occur in chromosomes and are typically the result of either errors that happen during meiosis or by exposure to mutagens such as chemicals or radiation. Chromosome breakage and duplications can cause several types of chromosome structural changes that are typically harmful to the individual. These types of mutations result in chromosomes with extra genes, not enough genes, or genes that are in the wrong sequence. Mutations can also produce cells that have abnormal numbers of chromosomes. Abnormal chromosome numbers typically occur as a result of nondisjunction or the failure of homologous chromosomes to separate properly during meiosis.

Egyptian Civilization essays

Egyptian Civilization essays Egyptian civilization formed along the Nile river and the earliest traces of human life in that region are from the Paleolithic Age, (Old Stone Age), about 300,000 B.C., at the very edges of the Nile Valley. Beyond, on both sides of the river the land was and still is desert. At that time the people moved from place to place, ate berries, roots, and any animals they could find, but stood close to their lifeline, the Nile. The lands along the Nile were rich enough to be farmed, so over time the people started to grow crops. They found ways to store the yearly floodwaters and then use them for the dry seasons. The farmers learned to lift water out of the Nile or wells and send it across the fields through a system of canals. In order for all of this to work out they had to work together, no one could do any of it alone. So as the farmers and people began to cooperate, an organization began to grow. They found leaders among them who directed the work. A form of government developed and due to that they soon began to build cities, to manufacture things, in time to trade with their neighbors. That is how it all started. Over a period from 3100 B.C. to 332 B.C. they grew in culture, arts, religion, science, The early Egyptian people grew food by the Nile and lived mainly by hunting for meat, fishing, and gathering wild plants. They kept a small number of cattle, sheep, or goats, and grew a few crops. Their crops were flax, barley, and a primitive kind of wheat called 'emmer.' They got the sheep and goats from the middle east, and their crops too. Farming provided most of the food and helped their population grow. Later on in time, the basic diet of the ordinary people was bread and beer. The wealthier ones ate more meat and drank wine instead of The most common clothes women wore were tunic dresses. Those were made by folding a rectangle of cloth in half, sewing it up at the sides, leaving ...

Vehicle Routing Software Assignment Example | Topics and Well Written Essays - 500 words

Vehicle Routing Software - Assignment Example These are several factors that are considered by clients when installing the vehicle routing system; durability, efficiency, installation and maintenance cost and detailed data. This software helps in; There are several software companies that offer vehicle routing service with both similar and different features .Some of the key features of vehicle routing software’s are constraint programming platform ,ability to tackle large and complex species problems, precise modeling ,operation research derived routing algorithm and immediate tangible benefits Appian is transport management software used for truck routing, logistic support analysis and designs. It is the easiest way to make fleet location and routing accessible to both the company and clients. It updates schedules automatically based on the real time GPS feed .It is able to mage easily territory overlaps quick return on investments. It allows incorporation Microsoft excel software. In apian there is resource scheduling and fleet sizing optimization software that provide crucial information for fleet scheduling, strategic growth plan and eliminating unnecessary cost. MJC2 is vendor that offers powerful planning and optimization solutions. It has advanced planning and scheduling software that is capable of providing automated scheduling and optimizing the operation with minimal manual intervention. This software is user friendly and has powerful scheduling control functionality. It also has e- enabled scheduler that allows web scheduling to be online and able to corporate databases and legacy system. It’s able to address the scheduling of very large distribution operation in real time and provide strategic supply chain management. Some other extra benefits are ability to quickly update round because demand varies, better utilization of resources and long term planning powers The vendor has product for real time routing and

The Importance of Water and the Hydrologic Cycle Essay

The Importance of Water and the Hydrologic Cycle - Essay Example NRDC arranged to test 1000 portable water bottles comprising of 103 brands available in the US market. NRDC conducted a detailed investigation that lasted for four years. Usually, producers of the bottled water maintain that their products are free of any chemical contaminants. Some of the samples collected were found to be contaminated with E-coli Bacteria, Arsenic, Nitrate, chloroform, phthalates, and some other kinds of bacteria that can cause serious illnesses to those who consume it. Infection with E-Coli bacteria can cause diarrhea, and vomit to children, elderly people and those who body immune system is weak. Substances such as Arsenic are considered carcinogenic and can lead to nervous, skin and reproductive issues. Nitrate interferes with blood's oxygen intake ability, especially in infants. Nitrates also increase cancer risk. The substance such as chloroform can cause cancer of the pancreas, colon; it may also cause miscarriage or birth defects in newborns (NRDC, 2013).NRD C clarifies that not all brands were contaminated with harmful substances. Almost 25% of the bottled water, with at least one sample tested of each brand, was found to be violating state standards. Some of them were comparable to tap water; however, NRDC clarifies that these brands are not without risk because most brands were tested only a few times; NRDC has called their tests as 'snapshot' tests. It is also likely that source water quality due to different surface water sources varies significantly time to time.

Effects of race on the perception of Guilt Essay Example for Free

Effects of race on the perception of Guilt Essay Affective mood disorders are mental disorders characterised by disturbances in mood and emotional states, unlike Schizophrenia, the most severe of mental disorders, which is distinguished by problems with thought processes. These affective mood disorders can include variations such as Bipolar disorders where the patient experiences two extreme states; mania accompanied with depression and Unipolar disorders where only the depressive state is present. There have been many suggestions as to the cause of these disorders. It has long been thought that there are two types of depression: reactive and endogenous. Reactive depression follows the psychodynamic view that depression relates to life events such as loss of a loved one and endogenous depression mirrors the cognitive approach where the individual attributes failures internally thus bringing on depression. However the DSM-IV only lists two sub-types of depression, which are reliant upon the length that the patient has suffered for. These are major depressive disorder and dysthymic disorder. Biochemical explanations are mainly associated with unipolar depression and were developed in the 1950s with the introduction of Tricyclic drugs, which were discovered to help those with depressive symptoms. It has been suggested that chemical imbalances in the brain cause these depressive symptoms. Neurotransmitters such as serotonin, norepinephrine and dopamine are believed to be of a higher level in patients with no signs of depression compared to lower levels in those with depression (Schildkraut, Green and Mooney, 1985, in Gleitman et al, 1999) However, it is only possible to investigate this by measuring the by-products of the metabolising neurotransmitters. Although it has been found that patients with depression have lower levels of these by-products, Cooper (1988, in Cardwell et al, 2000) carried out post-mortems on patients who had suffered from depression and found that there was no abnormality in the chemicals of the brain. Medications used to treat depression can be used in support of the biochemical hypothesis as drugs such as Lithium and Tricyclic antidepressants increase the levels of norepinephrine and serotonin in the brain implying that it was the shortage of these chemicals that was causing the depression. Rosenzwig, Leiman and Breedloves (1996, in Gleitman et al, 1999) experiment also supports this view as it was discovered that lowering the levels of the neurotransmitters works in reverse and can cause depression. However, these anti-depressant drugs cause an immediate increase in the levels of norepinephrine, following the biochemical hypothesis once the norepinephrine level is increased depressive symptoms should disappear. In fact it takes 2-3 weeks after first taking the drugs for an effect to be seen, yet within a couple of days after taking the drugs the norepinephrine levels have returned to their previous level. This hinders the biochemical hypothesis and suggests that it may not purely be a chemical imbalance that causes depression. Patients who suffer with bipolar depression also have low levels of norepinephrine during a depressed phase, returning to a higher level when in a manic stage, (Muscettola et al, 1984,in Gleitman et al, 1999) the switch between the manic and depressive phases occur very quickly and without external influences, indicating that it is in fact a biological rather than psychological reason that causes this switch to take place. Another strand to the biological approach is the question; does depression run in families? The biological explanation supports this suggestion. There have been numerous twin studies comparing concordance rates of MZ (identical twins) with DZ (non-identical) twins, all giving evidence for some genetic transmission. Evidence for a genetic link concerning bipolar disorders comes from a study carried out by Hodgkinson, Mullan and Gurling, (1990, in Gleitman et al, 1999); they discovered that patients who had bipolar disorder also had an enzyme deficiency accompanied by a type of colour blindness. All of these irregularities are caused by a defect on the X-chromosome. This indicates that the genetic cause of bipolar disorder also lies with the x-chromosome and may explain to a certain degree why it has been found that more women than men suffer from bipolar depression. However it is important to note that women, no matter what culture have a different social support structure to men, allowing them to talk more about their problems. Therefore it may simply be the case that more women report their problems than men, who keep their feelings of depression to themselves. This difference also occurs with unipolar depression and can be accounted for by the vast amounts of hormonal changes women endure through menstruation, child carrying and the menopause. McGuffin et al (1996) compared 109 pairs of twins and found a rate of 46 per cent concordance in MZ twins to that of 20 per cent in DZ twins; this study shows a genetic link for depression but that it is not the only factor. If depression were only caused by genetics then the concordance rates would be 100 per cent for MZ twins and 50 per cent for DZ twins, suggesting that other factors play an important role. This genetic link may be due to environmental factors as the patients are likely to live in a shared environment. This suggests that the concordance rates occur not because depression is hereditary but because it can be learnt. This however could also work in reverse; a relative may not suffer from depression because they have experienced depression and have learnt ways to cope with their feelings and experiences. This can also be illustrated by Siever, Davis, and Gorman, (1991, in Gleitman et al, 1999) who carried out twin studies that showed identical twins were four times more likely to both suffer from a mood disorder than non-identical twins. Identical twins have a closer shared environment than non-identical twins, which may account for the higher concordance rate amongst identical twins.

Marriage and Love in Elizabethan England Essays -- European History Es

Marriage and Love in Elizabethan England The movie, Shakespeare in Love, provides insight into the world of Elizabethan England. Through the character of Viola De Lessups the audience is shown how marriage was an institution entered into not for love, but as a strategic maneuver designed to enhance the lives of those who would benefit from a union, whether or not the beneficiaries were the people actually exchanging vows. As Queen, Elizabeth I chose not to enter into such a union. She expressed the thoughts and feelings she had about the subject in both her speech, â€Å"On Marriage† and her poem â€Å"On Monsieur’s Departure.† A comparison of the character of Viola to the real life Queen of England, Elizabeth I, can provide the reader a greater understanding of marriage and love in Elizabethan England. Queen Elizabeth and Viola both realized that their station in life would determine their prospects for marriage. Elizabeth had the power to decide not to marry. Viola’s marriage to Wessex decided for her as â€Å"a daughter’s duty and the Queen’s command†(Shakespeare).[2] Viola is the daughter of a wealthy merchant and while she is â€Å"not so well born† she is, as her nurse points out, â€Å"Well moneyed† which â€Å"is the same as well born† and â€Å"well married is more so† (Shakespeare). Likewise, Elizabeth knew that if the Queen of England were to marry she would have to make a union that would benefit her country. She felt pressure from Parliament to marry and addressed it in her speech, â€Å"On Marriage†, given to Parliament in 1559. She assured them that they could put that idea â€Å"clean out of [their] heads† for â€Å"whensoever it may please God to incline [her] heart to anothe r kind of life,† she intended â€Å"not to do... ...n that she understood that duty prevented her from such a marriage. In her poem, â€Å"On Monsieur’s Departure† she allows a glimpse into the pain it caused her to be unable to fully pursue a life of love. Works Cited: [1] William Shakespeare, â€Å"Sonnet CXVI†, The Longman Anthology of British Literature: The Early Modern Period, ed. David Damrosch, 2nd ed., vol 1B (NewYork: Longman, 2003) 1233-34. [2] Shakespeare in Love, dir. John Madden, Perf. Gwyneth Paltrow, Joseph Fiennes. Mirimax/Universal, 1998. [3] Elizabeth I, â€Å"On Marriage,† The Longman Anthology of British Literature: The Early Modern Period, ed. David Damrosch, 2nd ed., vol 1B (NewYork: Longman, 2003) 1084-85. [4] Elizabeth I, â€Å"On Monsieur’s Departure,† The Longman Anthology of British Literature: The Early Modern Period, ed. David Damrosch, 2nd ed., vol 1B (NewYork: Longman, 2003) 1081-82.

Human Physical Appearance Essay

The appearances of people is like their cover, that? s why it? s so important, because it? s what can be seen, the first thing you note in a person, and like it or not, it tells a lot. It? s like a book, most of the time it? s judged by it? s front page, the right thing would be to read the review where you can know the details of it? s content, but what do you notice first? That why I compare the human appearance with a book, and I affirm that you can? t know a person only by the way they look, because it?  s not always what it seems, wearing designers clothes not necessarily shows your economic status and you can? t know a person only by their physical appearance, because this can be modified by a very important factor, self-esteem According to the Pequeno Larousse Ilustrado (1976), Appearance is â€Å" the outside look of a person or thing†. In another words is peoples physics, but there are situations in which the person can be criticized by this, specially during the te enage, that are the years of physical and mental development, but the physical part is commonly judged. Are we really conscious of what we say about other people? , I? m not saying it? s wrong, because the physical appearance is important, but is it all?. The appearance are not always what they look like, and even more in the teenage, the psychiatrist Felix Loracca says that we are modeling are personality in function of what others expect from us. For example, psychologists say that women tend to want to be accepted, not so much for their personality but for them to feel prettier. Young men present a similar case, now that they pay a lot of attention to their physical appearance, without neglecting their clothes, their hair, etc. The way each and every one of the teenagers practice their personal care for their appearance changes from one to another, but basically the aim is the same one, â€Å"try to look good†. Teenagers not only change their clothes, but their response, their expressions, their vocabulary and recreative activities. The way they dress and the physical appearance become very important, it can be a way to express solidarity with their friends, or as a way to declare their growing independence from their families. Another important aspect to consider is that clothing not necessarily proves your economical status, and this is more discussable nowadays, because material things don’t tell who you really are, a good example of this is Mahatma Gandhi, who despite of everything he owned economically speaking, acted like the most humble person in the world. People use to go for others clothing. Physical appearance influence, but is not determinant when we meet someone, and you can’t determine their economy, or their education by this, because everybody can have any kind of clothes or material objects without mattering the cost of these, there is who say â€Å"fashion, what suits you† and people can dress according with what they feel comfortable with without caring what other people think about them. Elton Mayo says that human relationships are majorly based in ties that exist between the members of society, thanks to communication, that can have many ways: principally visual, linguistically, affective and by specially created languages for the development of complex societies, that’s why he affirms that there is some importance in the physical appearance. One of the human needs is to relate with other living creatures, like Maslow shows in his hierarchical pyramid, in the affiliation is the friendship, or the creation of relations with other people. But in any moment he affirms the importance of the physical appearance. The changes in how we look to others are related with our self-esteem and not to our auto-perception, that’s why any change in our physical appearance can affect our present ME status, if we don’t have the ability to accept and adapt to these changes, in the same way this affects directly in our emotional status. In conclusion, physical appearances are an important part of people presence, but they are not determinant in the way to judge them, for what we saw previously. They exist an infinity of questions that we can make as thinking beings, that we lead us to much more questions, but it all ends in ourselves, the answer is in each one of us, you decide what to base in, how to act with others and how you want them to see you, but without losing your own personality.

Should Men Be Allowed to Have More Than One Wife?

Argumentative Essay â€Å"Man fi have, nuff gal and gal ina bungle, gal from Rema and gal from Jungle†¦Ã¢â‚¬  Is a popular song by Jamaican reggae artiste Beenie Man. The song suggests that men should have multiple partners, a belief to which many Jamaican men also subscribe. A man having more than one wife is called Polygyny a form of polygamy that has been much debated in a lot of countries for years. Polygyny although illegal in Jamaica, remains acceptable in many cultures who argues that it should be practiced here.However, Men should not be allowed to have more than one wife in Jamaica as this would cause our morals and values to deteriorate and contribute to more troubled marriages which will have a negative impact on the children produced by these marriages. Polygyny is a form of polygamy in which a man has more than one wife (oxford dictionary); helps in the deterioration of moral beliefs and values which will affect our structured system negatively.Polygyny is In a hi ghly Christian based country such as Jamaica men being allowed to have more than one wife will significantly fail from uplifting our moral beliefs of a stable family unit of one man, one woman and children. According to the BOHRD (2011), Christianity contributes to more than half the religious population. This religious group firmly believes that Polygyny should not be practiced and a marriage is the union between one man and one woman in which we as a country has adopted.To start allowing men to be able to have more than one wife will only deteriote our moral standards and belisfs. in almost every country where polygamy is practiced it is only polygyny which is allowed and women marrying more than one man are forbidden. Right there is a violation gender inequality as enshrined in (OECD. 2010) a . This act will promote a hypocritical and biased society when it comes to issues of men vs women and hence will promote the abuse of our women. Polygamy also caused many problems within the home between the two wives.Usually there is at least one wife who is not happy with the arrangement. This is because the new wife is usually younger and has more to offer than the first wife. This jealousy causes a lot of friction in polygamist marriages. If the man buys something for one wife he needs to get something for the other. Even with buying something for both wives one of them often claims that the other received something better. The same thing is true for what he buys for each of their children. This impossibility of satisfying multiple wives at the same time causes many conflicts in polygamist marriages.The results of these conflicts are anywhere from the mistreatment of the others children to trying to convince her husband to divorce the other wife. This is so common that in Eastern Africa if two wives of the same man get along together people say that he must have used magic on them to accomplish this. Do you see a man having multiple wives to be any particular benef it to females, or is the benefit largely to the male â€Å"husband? † And in this economy, many men cannot afford to maintain one household and family, let alone two or three equally for each wife.How can broke men aspire to be polygynous when they do not have the wealth to meet the standards of such a situation? Children from such families can no longer earn good education; for there is little to go round among three-four households. They can not afford a balanced meal; being subsistence farmers, who relay on the bounty of the land, when drought heats, they will have to go without food if they don't get from charitable people who are also short. Women turn to have less self esteem, they see themselves through the male's eyes. hen a woman stands by the mirror instead of seeing herself through her own imagination, she thinks of how he will see her, so she is using his imagination, to define herself-worthy. In my opinion, polygamy served its purpose in those times, but now, it has become the decadence of the family community, and society at large, destroying self-esteem in women, and bringing unmeasurable suffering on children born from such families. There are reports of happy families but these are few and they could be in denial of reality, one would suggest.

1. Representing Your Country in Any Negotiation Is a Serious Commitment and a Major Responsibility. Discuss Your Action and Preparation for the Agenda. Essay Example

1. Representing Your Country in Any Negotiation Is a Serious Commitment and a Major Responsibility. Discuss Your Action and Preparation for the Agenda. Essay Example 1. Representing Your Country in Any Negotiation Is a Serious Commitment and a Major Responsibility. Discuss Your Action and Preparation for the Agenda. Essay 1. Representing Your Country in Any Negotiation Is a Serious Commitment and a Major Responsibility. Discuss Your Action and Preparation for the Agenda. Essay Essay Topic: Everything I Never Told You Negotiation is the process of getting what you want for what you want. Negotiation happen everyday in every facet of life. But when representing a country, it is a huge responsibility. Because when we represent a country, the country pride is at our shoulder. It will be more important if we are going to negotiate with other countries as it will affects the relations between countries in the future, and it will be watched closely by the international community, So what determines whether negotiation is successful or a failure? One of the key tools to success is quantity and depth of preparation you undertake before sit down with your counterparts to discuss your deal. Negotiation has two outcomes you either get what you want (for what you want) or you fail. Failure could result in both failing to obtain what you want or trading over. Negotiation is typically seen as a four stage process, the first step and perhaps the most important step in negotiation is preparation. A negotiation can be won or lost in the preparation phase. Effective negotiation involves thoughtful planning and preparation. Along with good negotiating skills of the negotiators at the bargaining table, good research analysis is an important determinant of a negotiation outcome. But what does preparation entail? Simply put its knowing what you want, what you wont accept and factors that might influence the outcome of the deal. According to Saner (2000), the three major phases of the negotiation life cycle are: Planning, Action and Assessment. The Planning process actually takes place before the major phase, i. e. Action, which is literally the negotiation period among the parties. The Planning phase includes identifying the problem area and awareness of conflicts, analysis of need and identifying the interests of the stakeholders, selecting the objective and strategy, selection of tactics and knowing the opponent. The Assessment phase consists in the evaluation of the negotiation, which determines whether the negotiation is complete or there is any scope for a future negotiation. Each negotiation is going to be different, no matter how often weve addressed similar situations. We will always be negotiating with people who have different styles, goals and objectives, and who are coming from different circumstances and have different standards. So, always take stock and gauge each negotiation as something unique. There are basically two types of conflict situations we may encounter in a negotiation. Conflicts can present themselves singularly, or may be a mixture of the two. It is vital that the negotiator carefully analyze the conflict issues, both individually and collectively, to fully appreciate the unique challenges they present. By analyzing the types of conflict into categories, negotiators can have a better understanding of the real measure of the disputes, and frame or focus their strategies more effectively. There are only two reasons why we enter into a negotiation. The first reason occurs when out of necessity, we have to. This could be due to either some immediate need, such as urgency to find a particular supplier, or it could be that we face severe cutbacks in personnel, if we cant increase our business. The second reason occurs when we are seeking out an opportunity. This situation may arise simply because an opportunity has sprung up, where we can increase our overall business at an opportune time. The reason for entering into a negotiation will affect both our approach and strategy, and also our relative negotiating power in comparison to our counterpart. We also need to ask ourselves whether the results of the negotiation we are conducting, will affect other negotiations or agreements later. Countries today have international interests. An agreement with the particular country, may affect how talks will impact or be influenced, with negotiations that will transpire later. With other countries, its vital that we, as negotiators, consider the impact or consequences of an agreement in developing our strategy. We either enter into negotiations because we have to, or because we want to. Part of our strategy will involve a careful analysis of our BATNA (Best Alternative to a Negotiated Agreement). If an agreement is absolutely essential, and we have few alternative options, in the event of talks collapsing, this will affect our strategy. Or, if the negotiated agreement is not essential because we have a strong option, and can walk away with confidence, this also influences the approach to our strategy. Negotiations are often private affairs with little fanfare, until an agreement is signed. There are also agreements that are advertised afterwards, to maximize the mutual benefit both sides obtain. On other occasions, negotiations may be held in strict secrecy. Then, there are the highly publicized occasions when the press becomes actively involved. It could be that one of the negotiating parties uses the powers of the press, to lever an advantage to sway and manipulate the outcome. We need only scan the daily newspapers, to understand the importance of how public involvement can influence and add intense pressure to some negotiations. The press can be utilized as a public forum to embarrass our opponents’ into action, or to deflect their strategy. Press releases are another means to use as an effective strategy in the negotiation process. Time has an impact on the course of negotiations from two perspectives. First there are deadlines that might be imposed, to either make or break an agreement. Offers with expiry dates may be tendered. Secondly, we all know that Time is money. Negotiations use up time, and if a plant is shut down while the clock is ticking because of a strike, then this is costing money. Or, it could be due to some other resource issue, such as waiting for badly needed components, in order to resume production. The point to remember is that the longer the negotiations drag out; time will negatively affect the bottom line. But in a negotiation, everything can happen, so we must be ready if the negotiation process extends to a period of time. It can also take a long time for it to reach an agreement and finalized. We should never automatically assume that a negotiation is going to result into a successful agreement. Always ask yourself, Okay! If all else fails, what other choices or options do I have? This means that it is most desirable to have some options or alternatives to turn to when the talks collapse. To use the popular parlance of negotiation, this means we need to know our BATNA which is the acronym for Best Alternative to a Negotiated Agreement, a term popularized by Roger Fisher and William Ury in their best selling novel titled, Getting to Yes Negotiating Agreement Without Giving In. Knowing our own interests and figuring out their real interests is not enough. We cant just make up a simple list and figure thats all we have to do. We need to prioritize and rank this list according to importance. By understanding our own priorities and our counterparts priorities we can more effectively consider our concessions in terms of their strengths relative to each side. The idea is to give up on less important concessions which may have value to them, while getting the other side to give us concessions which are more important to us. When agreement or conclusions have been reached and you are ready to end your negotiation, review the agreement that has been reached. Then, end your negotiation on a positive note. Commending those involved and emphasizing the progress made. Once you have reached agreement over the terms of your negotiation you must then close the deal. This can often be the cause of many frustrations and broken deals as once you have agreed a deal – how do you ensure it’s enforced? Closing your negotiation implies that you will not improve your offer or you have what you want. It’s important to know when to do this as closing too early could alert your opponent into realizing the deal is not in their favor and they may attempt to pull out of the deal. Closing too late could have the opposite affect and you may end up trading over the odds, offering needless concessions which go against your original proposal. As has been told earlier, preparation is the most important part of a negotiation. Be ready, because it will determine what will happen at the negotiation table. All of our action will be based on our preparation before the meeting takes place. When representing a country in negotiation, its not that we went there as an individual, but we are the representative of a country that want something or resolving a disputes with other countries that clearly will not just agree just like that.

Does Your Business Need a Proofreader

Does Your Business Need a Proofreader Does Your Business Need a Proofreader? Does your business need a proofreader? Yes. Yes, it does. That’ll be all. Thank you for reading. What? You want to know why your business needs a proofreader? Okay, we’ll set out a few reasons below. But by the end of this post, you’ll wonder how you could ever have questioned it! 1. Polished Professionalism Whatever your business, you need to make a good first impression. And the first thing anyone will see is often something you’ve written (e.g., a company website or press release). Think about it this way: If you were meeting a client for the first time, would you turn up with your hair in a mess, odd socks on, and a coffee stain on your shirt? No? Well, you need to apply the same standards to your writing! Unlike a bad hair day, you cant cover up typos with a hat.(Photo: Bruce Guenter/flickr) 2. Typos Can Be Costly Errors in business writing can be costly in two ways. First of all, it can cost you the trust of customers and clients. Mistakes in website copy, for example, may make customers think twice about using your services, since it suggests a lack of care or attention to detail. More literally, though, typos can be expensive: For instance, the publisher Penguin once had to destroy 7,000 copies of The Pasta Bible at a cost of $20,000 because the book accidentally recommended using â€Å"freshly ground black people† instead of â€Å"freshly ground black pepper.† Pasta is definitely better seasoned with pepper. It’s fair to say that a thorough proofreader could have saved everyone involved a lot of trouble! 3. Proofreading Is a Skill We don’t blame anyone for not knowing all the rules about comma usage. Nor do we expect everyone we meet to be as keen on correct pronoun choice as we are. That’s because it takes a special kind of person to obsess over the details of spelling, grammar, and punctuation: a proofreader. In other words, the only way to be sure of great proofreading is to hire a professional. This also lets you and your colleagues concentrate on other work, boosting efficiency across your business. 4. Letting Your Content Shine! If you’ve gone to a lot of effort writing copy, you owe it to yourself and your business to let it shine. But self-editing is difficult, especially if you’re too close to what you’ve written. A professional proofreader, on the other hand, will bring a fresh pair of eyes to your work. This means we can spot errors you might miss, ensuring that your message comes through loud and clear. Eyes, fresh and ready for proofreading. Still not convinced? Then send us a 500-word sample and we’ll show you what we can do for free.

Critical Rhetorical Analysis Essay Example | Topics and Well Written Essays - 1000 words - 1

Critical Rhetorical Analysis - Essay Example Thus, the use of outsourcing has become more relevant in today’s business environment and industries in the international market. Outsourcing usually has numerous advantages to the companies that are outsourcing but this depends on the manner the particular company concerned goes about in the outsourcing. Through outsourcing, the company is able to benefit from reduced prices and better quality goods and services as well as increased selection of products on offer to the consumers. The challenges for outsourcing usually stem from the fact that the company has to meet the legal, business and cultural requirements of the new market that it outsources in. Even if a company manages to overcome the challenges of outsourcing, it may fail to overcome the risks involved such as the loyalty of the staff in the outsourced market as well as other hidden costs. There could be serious problems if the labor or members that work in the outsourced market are not chosen in an appropriate manner or that the initiative is not properly articulated to the members of the company. Kripalani argues that outsourcing of jobs has been met with skepticism in the United States majorly due to the fact that the government and industrialists alike believe that through outsourcing, the countries that outsource take away the job opportunities available to citizens. However, he argues that the United States government should look at the finer details and benefits that may be derived from outsourcing as when handled well, the nation stands to benefit just as the nation that it has outsourced jobs to (Kripalani, 64). His argument is supported by the fact that the ruling party in India has appreciated the economic importance of having a free trade area which allows outsourcing as a creator of employment opportunities for all. Through outsourcing in India, corporations headquartered in the United States stand to

Research topics and explanation Paper Example | Topics and Well Written Essays - 500 words

Topics and explanation - Research Paper Example The increasing trend of students being expelled for exam cheating in schools is a matter that has aroused debate in the society. Since the students are expected to be the future leaders, there is need to give them sound bringing up and in the event they commit some mistakes especially in learning institution. It is therefore important to resort to other rehabilitative measures like counseling in cases of examination cheating instead of the ultimate destructive move of expelling them. This issue is therefore critical for the general welfare of the society. Various states have been experiencing high cases of accidents caused by reckless motorists. Most of these accidents can be attributed to lack of safety measures like helmet for the motorcyclists and the passengers (Savageau, 2007). The society has kept blaming transport department and related authorities on laxity of enforcing safety measure rules with particular emphasis on wearing helmet. This topic is relevant as if it is addressed it will significantly mitigate cases of motorcyclists and passengers having head injuries at the slightest contact with the ground or any other object in the event of an accident. The sensitivity of the head to injuries also makes it important to address the issue of wearing helmet as a compulsory requirement for any motorcyclist (Merson, Black, & Mills, 2012). The audience of this subject should be the motorcyclists, general public who forms the passenger community and the transport governing authorities who should ensure rules and regulations on road safety are implemented. The increasing call for safety measures in the roads requires that all the motorcyclists enlist the use of helmet. It is in the interest of the general public that helmets are made available for the passenger and the motorcyclists to minimize case of fatalities in